Nanoceria-Based Phospholipase-Mimetic Cell Membrane Disruptive Antibiofilm Agents

Membrane-mimetic nanocarriers formed by a dipalmitoylated cell-penetrating peptide.

Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity.

Galactosaminogalactan and Pel are cationic heteropolysaccharides produced by the opportunistic pathogens Aspergillus fumigatus and Pseudomonas aeruginosa, respectively. These exopolysaccharides both contain 1,4-linked N-acetyl-d-galactosamine and play an important role in biofilm formation by these organisms. Proteins containing glycoside hydrolase domains have recently been identified within t...

Influences of membrane mimetic environments on membrane protein structures.

The number of membrane protein structures in the Protein Data Bank is becoming significant and growing. Here, the transmembrane domain structures of the helical membrane proteins are evaluated to assess the influences of the membrane mimetic environments. Toward this goal, many of the biophysical properties of membranes are discussed and contrasted with those of the membrane mimetics commonly u...

Matrix Metalloproteinase-7 Activation of Mouse Paneth Cell Pro- -defensins SER2ILE PROTEOLYSIS ENABLES MEMBRANE-DISRUPTIVE ACTIVITY*

Colby S. Weeks, Hiroki Tanabe, Jason E. Cummings, Steve P. Crampton , Tanya Sheynis**, Raz Jelinek**, T. Kyle Vanderlick, Melanie J. Cocco , and Andre J. Ouellette ‡‡1 From the Departments of Pathology & Laboratory Medicine, Molecular Biology & Biochemistry, and Microbiology & Molecular Genetics, and Center for Immunology, University of California, Irvine, California 92697-4800, the Third Depar...

Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death.

Lysosomes are acidic organelles essential for degradation, signalling and cell homoeostasis. In addition, they play a key role in cell death. Permeabilization of the lysosomal membrane and release of hydrolytic enzymes to the cytosol accompanies apoptosis signalling in several systems. The regulatory mechanism of lysosomal stability is, however, poorly understood. Lipophilic or amphiphilic comp...